Mannose-binding protein gene polymorphism in South African systemic lupus erythematosus
نویسندگان
چکیده
منابع مشابه
Mannose binding lectin gene polymorphism and preclinical carotid atherosclerosis in patients with systemic lupus erythematosus.
Patients with systemic lupus erythematosus (SLE) have increased risk of atherosclerosis and CVD that cannot be explained by traditional risk factors. Previous studies indicated that mannose binding lectin (MBL) may modify the development of atherosclerosis. This study was designed to investigate association of MBL gene polymorphism with occurrence of preclinical atherosclerosis in SLE. The stud...
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Objectives—Polymorphism of the phagocyte IgG receptor FcãRIIa may modulate immune complex mediated inflammation, particularly when immune complexes contain IgG2. Previous studies suggest that this polymorphism may be an important risk factor for lupus nephritis. FcãRIIa is biallelic, the alleles R and H each having a gene frequency of about 50%. Nephritis has been associated with an increased f...
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ABSTRACT Background and Objectives: C-C chemokine receptor type 5 (CCR5) is a chemokine receptor expressed at high levels on the surface of T-cells. A 32-bp deletion in the coding region of the CCR5 (CCR5Δ32) leads to production of an incomplete protein that is not expressed on the cell surface. CCR5Δ32 may be involved in devel...
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ژورنال
عنوان ژورنال: Rheumatology
سال: 1998
ISSN: 1460-2172
DOI: 10.1093/rheumatology/37.4.465